Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 5/20 | 0.67 |
| ▸ | CCKBR | P32239 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14121883 | 1.00 | PDE5A (0.67) | PDE5ACCKBRKDM4EHSD17B10TSHR | |
| SCHEMBL14122143 | 1.00 | PDE5A (0.67) | PDE5ACCKBRKDM4EHSD17B10TSHR | |
| SCHEMBL14121446 | 1.00 | PDE5A (0.67) | PDE5ACCKBRKDM4EHSD17B10TSHR | |
| SCHEMBL17760562 | 0.93 | PDE5A (0.69) | PDE5ACCKBRKDM4EHSD17B10TSHR | |
| SCHEMBL17760548 | 0.93 | PDE5A (0.69) | PDE5ACCKBRKDM4EHSD17B10TSHR | |
| SCHEMBL4047718 | 0.90 | CCKBR (0.71) | PDE5ACCKBRKDM4EHSD17B10TSHR | |
| SCHEMBL5033704 | 0.88 | PDE5A (0.64) | PDE5ACCKBRKDM4EHSD17B10TSHR | |
| SCHEMBL17760604 | 0.85 | KDM4E (0.70) | PDE5ACCKBRKDM4EHSD17B10TSHR | |
| SCHEMBL17624908 | 0.85 | KDM4E (0.70) | PDE5ACCKBRKDM4EHSD17B10TSHR | |
| SCHEMBL5116651 | 0.84 | CCKBR (0.74) | PDE5ACCKBRKDM4EHSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9169247-B2 | Tetrahydro-beta-carboline derivatives, synthesis and use thereof | SOUTHERN RESEARCH INSTITUTE (US) | 2015-10-27 | — | — | US | disclosed |
| US-9169247-B2 | Tetrahydro-beta-carboline derivatives, synthesis and use thereof | SOUTHERN RESEARCH INSTITUTE (US) | 2015-10-27 | — | — | US | disclosed |
| US-20120309781-A1 | TETRAHYDRO-beta-CARBOLINE DERIVATIVES, SYNTHESIS AND USE THEREOF | SOUTHERN RESEARCH INSTITUTE (US) | 2012-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309781-A1 | TETRAHYDRO-beta-CARBOLINE DERIVATIVES, SYNTHESIS AND USE THEREOF | PDE5A, PDE3A, PDE3B | PDE5A 1/4885CCKBR 2503/4885KDM4E 839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.