Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.36 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.35 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | GPR183 | P32249 | 1/20 | 0.35 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.35 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.30 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6445309 | 0.80 | — | — | |
| Tromethamine SCHEMBL7078938 | 0.79 | S1PR1 (0.45) | MEN1LMNAKMT2AKDM4EPOLB | |
| Water SCHEMBL27658649 | 0.78 | — | — | |
| Tromethamine SCHEMBL6290298 | 0.75 | LMNA (0.43) | MEN1LMNAKMT2AKDM4EPOLB | |
| Tromethamine SCHEMBL7181961 | 0.75 | LMNA (0.43) | MEN1LMNAKMT2AKDM4EPOLB | |
| Tromethamine SCHEMBL7199000 | 0.67 | MEN1 (0.43) | MEN1LMNAKMT2AKDM4EPOLB | |
| SCHEMBL1338455 | 0.66 | HRH3 (0.35) | — | |
| Tromethamine SCHEMBL7652452 | 0.65 | MEN1 (0.42) | MEN1LMNAKMT2AKDM4EPOLB | |
| SCHEMBL3154739 | 0.65 | TSHR (0.50) | — | |
| SCHEMBL327802 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919972-A1 | PROCESS FOR MANUFACTURING A THERMOPLASTIC ELASTOMERIC MATERIAL | Pirelli & C. S.p.A. (IT) | 2008-05-14 | — | — | EP | claimed |
| WO-2007025556-A1 | PROCESS FOR MANUFACTURING A THERMOPLASTIC ELASTOMERIC MATERIAL | PIRELLI & C. S.P.A. (IT) | 2007-03-08 | — | — | WO | claimed |
| EP-1919972-A1 | PROCESS FOR MANUFACTURING A THERMOPLASTIC ELASTOMERIC MATERIAL | Pirelli & C. S.p.A. (IT) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007025556-A1 | PROCESS FOR MANUFACTURING A THERMOPLASTIC ELASTOMERIC MATERIAL | PIRELLI & C. S.P.A. (IT) | 2007-03-08 | — | — | WO | disclosed |