Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL9193688 | 0.83 | MEN1 (0.42) | MEN1LMNAKMT2AS1PR1 | |
| Tromethamine SCHEMBL7199000 | 0.81 | MEN1 (0.43) | MEN1LMNAKMT2ACES2CES1 | |
| SCHEMBL3209827 | 0.76 | CES2 (0.41) | CES2CES1 | |
| Tromethamine SCHEMBL8531348 | 0.75 | MEN1 (0.42) | MEN1LMNAKMT2AS1PR1 | |
| Tromethamine SCHEMBL7762678 | 0.73 | LMNA (0.40) | MEN1LMNAKMT2ACES2KDM4E | |
| Tromethamine SCHEMBL457183 | 0.73 | MEN1 (0.50) | MEN1LMNAKMT2AS1PR1 | |
| Tromethamine SCHEMBL7078938 | 0.72 | S1PR1 (0.45) | MEN1LMNAKMT2ACES2CES1 | |
| Tromethamine SCHEMBL7029632 | 0.72 | MEN1 (0.34) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL6864894 | 0.71 | MEN1 (0.48) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL2792064 | 0.71 | MEN1 (0.37) | MEN1LMNAKMT2ACES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002038637-A1 | METHOD FOR COPOLYMERIZING PROPENE AND/OR ETHENE WITH 1-OLEFINS ON METALLOCENE CARRIER CATALYSTS | BASELL POLYPROPYLEN GMBH (DE) | 2002-05-16 | — | — | WO | claimed |