Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 10/20 | 0.36 |
| ▸ | MMP9 | P14780 | 9/20 | 0.36 |
| ▸ | MMP1 | P03956 | 3/20 | 0.36 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.34 |
| ▸ | BCL2 | P10415 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 3/20 | 0.31 |
| ▸ | MMP13 | P45452 | 3/20 | 0.31 |
| ▸ | MMP8 | P22894 | 2/20 | 0.31 |
| ▸ | MMP14 | P50281 | 2/20 | 0.31 |
| ▸ | MMP16 | P51512 | 2/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
| ▸ | STS | P08842 | 1/20 | 0.30 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5034688 | 0.79 | MMP2 (0.41) | MMP2MMP9MMP1ADAMTS5MMP3 | |
| SCHEMBL5033278 | 0.78 | ADAMTS5 (0.42) | MMP2MMP9MMP1ADAMTS5MMP3 | |
| SCHEMBL5033295 | 0.77 | ADAMTS5 (0.43) | MMP2MMP9MMP1ADAMTS5MMP3 | |
| SCHEMBL5033274 | 0.68 | ADAMTS5 (0.44) | MMP2MMP9MMP1ADAMTS5MMP3 | |
| SCHEMBL5033708 | 0.67 | MMP2 (0.44) | MMP2MMP9MMP1ADAMTS5MMP3 | |
| SCHEMBL5033703 | 0.67 | MMP2 (0.44) | MMP2MMP9MMP1ADAMTS5MMP3 | |
| SCHEMBL5033291 | 0.67 | ADAMTS5 (0.43) | MMP2MMP9MMP1ADAMTS5MMP3 | |
| SCHEMBL7078773 | 0.63 | — | — | |
| SCHEMBL5033284 | 0.62 | CYP2D6 (0.31) | — | |
| SCHEMBL4891268 | 0.61 | ADAMTS5 (0.38) | MMP2MMP9MMP1ADAMTS5MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1918278-A1 | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases | Novartis AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| US-6410580-B1 | ANTIINFLAMMATORY AGENTS, RHEUMATIC DISEASES | NOVARTIS AG (CH) | 2002-06-25 | — | — | US | disclosed |