Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | KIF11 | P52732 | 1/20 | 0.54 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | NPY1R | P25929 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12468706 | 0.85 | MAPT (0.73) | MAPTKDM4EL3MBTL1ALDH1A1EPHX2 | |
| SCHEMBL11137428 | 0.84 | MAPT (0.71) | MAPTKDM4EL3MBTL1ALDH1A1CYP3A4 | |
| SCHEMBL9955776 | 0.81 | EPHX2 (0.62) | MAPTKDM4EL3MBTL1ALDH1A1HPGD | |
| SCHEMBL169453 | 0.81 | EPHX2 (0.73) | MAPTKDM4EL3MBTL1ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL30367847 | 0.80 | EPHX2 (0.71) | MAPTKDM4EL3MBTL1ALDH1A1HPGD | |
| SCHEMBL4334835 | 0.80 | KMT2A (0.53) | MAPTKDM4EALDH1A1HPGDEPHX2 | |
| SCHEMBL18031171 | 0.79 | MAPT (0.86) | MAPTKDM4EL3MBTL1ALDH1A1EPHX2 | |
| SCHEMBL19371462 | 0.79 | L3MBTL1 (1.00) | MAPTKDM4EL3MBTL1ALDH1A1CYP2C9 | |
| SCHEMBL30140846 | 0.79 | EPHX2 (0.69) | MAPTKDM4EL3MBTL1HPGDEPHX2 | |
| SCHEMBL30042800 | 0.77 | MAPT (0.45) | MAPTKDM4EL3MBTL1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101687816-A | Triaminopyrimidine derivatives as the CDC25 inhibitors of phosphatases | IPSEN PHARMA SAS | 2010-03-31 | — | — | CN | claimed |
| CN-119998281-A | Neurotrophic receptor tyrosine kinase (NTRK) inhibitors and methods of use thereof | 贝勒医学院 | 2025-05-13 | — | — | CN | disclosed |
| CN-114249672-B | Riluzole intermediate compound | 鲁南制药集团股份有限公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-114249677-B | Riluzole intermediate compound and preparation method thereof | 鲁南制药集团股份有限公司 | 2023-11-07 | — | — | CN | disclosed |
| CN-114249702-B | N-aryl- [2,4 '-dithiazole ] -2' -amine compound and preparation and application thereof | 沈阳药科大学 | 2023-09-05 | — | — | CN | disclosed |
| CN-114502543-A | Targeted protein compounds, pharmaceutical compositions and therapeutic applications thereof | 拜欧斯瑞克斯公司 | 2022-05-13 | — | — | CN | disclosed |
| CN-114249672-A | Riluzole intermediate compound | 鲁南制药集团股份有限公司 | 2022-03-29 | — | — | CN | disclosed |
| CN-114249677-A | Riluzole intermediate compound and preparation method thereof | 鲁南制药集团股份有限公司 | 2022-03-29 | — | — | CN | disclosed |
| CN-114249702-A | N-aryl- [2,4 '-bithiazole ] -2' -amine compound and preparation and application thereof | 沈阳药科大学 | 2022-03-29 | — | — | CN | disclosed |
| CN-101687816-A | Triaminopyrimidine derivatives as the CDC25 inhibitors of phosphatases | IPSEN PHARMA SAS | 2010-03-31 | — | — | CN | disclosed |
| CN-100509808-C | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2009-07-08 | — | — | CN | disclosed |
| US-7371751-B2 | Thiazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-05-13 | — | — | US | disclosed |
| EP-1694673-B1 | THIAZOLE DERIVATES | HOFFMANN LA ROCHE (CH) | 2008-01-16 | — | — | EP | disclosed |
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | ARENA PHARMACEUTICALS, INC. | 2007-01-11 | — | — | US | disclosed |
| CN-1890236-A | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2007-01-03 | — | — | CN | disclosed |
| EP-1694673-A1 | NOVEL THIAZOLE DERIVATES | F.HOFFMANN-LA ROCHE AG (CH) | 2006-08-30 | — | — | EP | disclosed |
| US-20050153962-A1 | Thiazole derivatives | HOFFMANN-LA ROCHE INC. | 2005-07-14 | — | — | US | disclosed |
| WO-2005058887-A1 | NOVEL THIAZOLE DERIVATES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | MCHR1, GPR119, MCHR2 | MAPT 680/4885KDM4E 1012/4885L3MBTL1 3309/4885 |
| US-20050153962-A1 | Thiazole derivatives | CNR1, CNR2, GPR119 | MAPT 3183/4885KDM4E 3200/4885L3MBTL1 2979/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.