Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP3 | P15309 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | MMP16 | P51512 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5112475 | 0.80 | PTGS2 (0.46) | MAPK1CXCL8MMP1MMP2MMP9 | |
| SCHEMBL5983552 | 0.80 | PTGS2 (0.46) | MAPK1CXCL8MMP1MMP2MMP9 | |
| SCHEMBL30222272 | 0.80 | PTGS2 (0.46) | MAPK1CXCL8MMP1MMP2MMP9 | |
| SCHEMBL9448847 | 0.80 | MAPT (0.43) | MAPK1CXCL8MMP1MMP2MMP9 | |
| SCHEMBL9446005 | 0.80 | NR4A2 (0.42) | ACP3MAPK1TSHR | |
| SCHEMBL9446007 | 0.80 | NR4A2 (0.42) | ACP3MAPK1TSHR | |
| SCHEMBL7822153 | 0.79 | PTGS2 (0.44) | CXCL8MMP1MMP2MMP9MMP8 | |
| SCHEMBL1063487 | 0.79 | PTGS2 (0.44) | MAPK1CXCL8MMP1MMP2MMP9 | |
| SCHEMBL20640867 | 0.78 | HPGD (0.37) | — | |
| SCHEMBL8053801 | 0.78 | ACP3 (0.65) | ACP3MMP2MMP9MMP12TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896392-A1 | A-[E)-2-(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPTHALENYL)-1-PROPENYL]BENZOIC ACID ANALOGS AND METHOD OF MANUFACTURE AND AND USE THEREOF | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2008-03-12 | — | — | EP | disclosed |
| WO-2007005568-A1 | A-[(E)-2-(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPTHALENYL)-1-PROPENYL]BENZOIC ACID ANALOGS AND METHOD OF MANUFACTURE AND AND USE THEREOF | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2007-01-11 | — | — | WO | disclosed |