Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.51 |
| ▸ | DRD4 | P21917 | 10/20 | 0.51 |
| ▸ | DRD3 | P35462 | 10/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | IL4I1 | Q96RQ9 | 2/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5032611 | 0.81 | DRD2 (0.53) | DRD2DRD4DRD3SMN1; SMN2MAPT | |
| SCHEMBL4271450 | 0.81 | DRD2 (0.73) | DRD2DRD4DRD3SMN1; SMN2MAPT | |
| SCHEMBL4271439 | 0.77 | DRD2 (0.46) | DRD2DRD4DRD3SMN1; SMN2MAPT | |
| SCHEMBL13625846 | 0.73 | SMN1; SMN2 (0.53) | DRD2DRD4DRD3SMN1; SMN2MAPT | |
| SCHEMBL4307364 | 0.73 | NOTUM (0.56) | DRD2DRD4DRD3SMN1; SMN2MAPT | |
| SCHEMBL4277851 | 0.73 | CACNA2D1 (0.49) | DRD2DRD4DRD3SMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL8577214 | 0.72 | DRD2 (0.56) | DRD2DRD4DRD3SMN1; SMN2MAPT | |
| SCHEMBL8229282 | 0.72 | DRD2 (0.49) | DRD2DRD4DRD3SMN1; SMN2MAPT | |
| SCHEMBL13609767 | 0.72 | DRD2 (0.47) | DRD2DRD4DRD3SMN1; SMN2MAPT | |
| SCHEMBL5048004 | 0.72 | ATM (0.41) | DRD2DRD4DRD3SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007759-A1 | ISOXAZOLE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Neuromed Pharmaceuticals, Ltd. (CA) | 2008-12-31 | — | — | EP | claimed |
| WO-2007118323-A1 | ISOXAZOLE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2007-10-25 | — | — | WO | claimed |