Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.60 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.56 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.56 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.56 |
| ▸ | PPARG | P37231 | 7/20 | 0.54 |
| ▸ | PPARD | Q03181 | 7/20 | 0.54 |
| ▸ | PPARA | Q07869 | 7/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | TLR2 | O60603 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | FABP4 | P15090 | 2/20 | 0.54 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.54 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Azelaic Acid SCHEMBL347853 | 1.00 | TSHR (0.60) | TSHRLMNANFKB1PMP22GPR84 | |
| Octanedioate SCHEMBL28872523 | 1.00 | TSHR (0.60) | TSHRLMNANFKB1PMP22GPR84 | |
| Propylene Glycol SCHEMBL27855295 | 1.00 | TSHR (0.60) | TSHRLMNANFKB1PMP22GPR84 | |
| Sebacic Acid SCHEMBL347212 | 1.00 | TSHR (0.60) | TSHRLMNANFKB1PMP22GPR84 | |
| Sebacic Acid SCHEMBL29223184 | 0.98 | TSHR (0.57) | TSHRLMNANFKB1PMP22GPR84 | |
| Adipic Acid SCHEMBL346488 | 0.97 | LMNA (0.58) | TSHRLMNANFKB1PMP22GPR84 | |
| Adipic Acid SCHEMBL27922095 | 0.97 | LMNA (0.58) | TSHRLMNANFKB1PMP22GPR84 | |
| Adipic Acid SCHEMBL10936251 | 0.97 | LMNA (0.58) | TSHRLMNANFKB1PMP22GPR84 | |
| Adipic Acid SCHEMBL28436413 | 0.95 | LMNA (0.55) | TSHRLMNANFKB1PMP22GPR84 | |
| Sebacic Acid SCHEMBL20164089 | 0.93 | GPR84 (0.70) | TSHRLMNANFKB1PMP22GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080200605-A1 | Method For Producing An Aqueous Polymer Dispersion | BASF AKTIENGESELLSCHAFT (DE) | 2008-08-21 | — | — | US | disclosed |