Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ASPH | Q12797 | 1/20 | 0.37 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 3/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMO | O15229 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30047616 | 0.82 | ALDH1A1 (0.39) | ALDH1A1ALOX15KDM4EASPHKDM8 | |
| SCHEMBL2114463 | 0.81 | NAPRT (0.48) | NAPRTALDH1A1KDM4EASPHKDM8 | |
| SCHEMBL26618917 | 0.80 | NAPRT (0.36) | NAPRTALDH1A1ALOX15KDM4EASPH | |
| SCHEMBL16414338 | 0.79 | NAPRT (0.38) | NAPRTALDH1A1KDM4EASPHKDM8 | |
| SCHEMBL2338841 | 0.79 | NAPRT (0.38) | NAPRTALDH1A1KDM4EASPHKDM8 | |
| SCHEMBL27189436 | 0.75 | KDM4E (0.46) | NAPRTALDH1A1ALOX15KDM4EASPH | |
| SCHEMBL21723089 | 0.75 | CA12 (0.42) | NAPRTALDH1A1ALOX15KDM4ELMNA | |
| SCHEMBL5112165 | 0.71 | CA1 (0.34) | ALDH1A1ALOX15KDM4EASPHKDM8 | |
| SCHEMBL14741153 | 0.71 | SSTR4 (0.38) | ALDH1A1ALOX15KDM4EKMT2AMEN1 | |
| SCHEMBL105255 | 0.70 | CES2 (0.64) | ALDH1A1ALOX15CES2CES1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102675237-A | 2, 4-diphenyl oxazoline new compound, synthetic method and acaricidal activity thereof | NANJING UNIVERSITY OF TECHNOLOGY | 2012-09-19 | — | — | CN | disclosed |
| EP-1699767-A4 | PROCESS FOR THE PREPARATION OF PYRIDOPYRIMIDONES | SCIOS INC (US) | 2008-12-03 | — | — | EP | disclosed |
| US-7119199-B2 | Process for the preparation of pyridopyrimidones | SCIOS INC (US) | 2006-10-10 | — | — | US | disclosed |
| EP-1699767-A2 | PROCESS FOR THE PREPARATION OF PYRIDOPYRIMIDONES | Scios, Inc. (US) | 2006-09-13 | — | — | EP | disclosed |
| US-20050176957-A1 | Process for the preparation of pyridopyrimidones | SCIOS INC. | 2005-08-11 | — | — | US | disclosed |
| WO-2005065416-A2 | PROCESS FOR THE PREPARATION OF PYRIDOPYRIMIDONES | SCIOS INC. (US) | 2005-07-21 | — | — | WO | disclosed |
| EP-1537084-A1 | SUBSTITUTED 2-ALKYLAMINE NICOTINIC AMIDE DERIVATIVES AND USE THERE OF | Amgen Inc. (US) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004007458-A1 | SUBSTITUTED 2-ALKYLAMINE NICOTINIC AMIDE DERIVATIVES AND USE THERE OF | AMGEN INC. (US) | 2004-01-22 | — | — | WO | disclosed |
| EP-1358184-A1 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE | Amgen Inc. (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002066470-A1 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2002-08-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176957-A1 | Process for the preparation of pyridopyrimidones | PDXK, PNPO, AGPS | NAPRT 136/4885ALDH1A1 1829/4885ALOX15 1911/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.