Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 9/20 | 0.41 |
| ▸ | LMNA | P02545 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5046060 | 0.90 | KLKB1 (0.43) | ALDH1A1MAPTLMNASMN1; SMN2RAB9A | |
| SCHEMBL5043820 | 0.88 | KLKB1 (0.48) | ALDH1A1MEN1KMT2AMAPTLMNA | |
| SCHEMBL5048642 | 0.81 | CDC25A (0.44) | ALDH1A1MAPTLMNASMN1; SMN2RAB9A | |
| SCHEMBL5039868 | 0.81 | ALDH1A1 (0.48) | ALDH1A1MEN1KMT2AMAPTLMNA | |
| SCHEMBL5047785 | 0.80 | SMN1; SMN2 (0.45) | ALDH1A1MEN1KMT2AMAPTLMNA | |
| SCHEMBL5039689 | 0.79 | MAPT (0.43) | ALDH1A1KMT2AMAPTSMN1; SMN2RAB9A | |
| SCHEMBL5046920 | 0.79 | KLKB1 (0.46) | ALDH1A1MEN1KMT2AMAPTLMNA | |
| SCHEMBL5048727 | 0.79 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2AMAPTLMNA | |
| SCHEMBL5049186 | 0.78 | NPC1 (0.41) | ALDH1A1MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL5048718 | 0.77 | EIF4E (0.41) | ALDH1A1KMT2AMAPTSMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583762-B1 | PYRROLYL-THIAZOLES AND THEIR USE AS CB 1 RECEPTOR INVERSE AGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-09 | — | — | EP | claimed |