Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | NAAA | Q02083 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.45 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.45 |
| ▸ | EYA3 | Q99504 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MLYCD | O95822 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL27738439 | 0.88 | TMEM97 (0.48) | TMEM97SIGMAR1NAAAPTPN1SIRT3 | |
| SCHEMBL1856867 | 0.87 | TMEM97 (0.50) | TMEM97SIGMAR1NAAAPTPN1SIRT3 | |
| SCHEMBL1860426 | 0.85 | HDAC3 (0.50) | TMEM97SIGMAR1NAAAPTPN1SIRT3 | |
| SCHEMBL4331561 | 0.84 | TMEM97 (0.45) | TMEM97SIGMAR1NAAAPTPN1SIRT3 | |
| SCHEMBL1853850 | 0.79 | NAAA (0.43) | TMEM97SIGMAR1NAAAPTPN1SIRT3 | |
| SCHEMBL5044615 | 0.78 | TMEM97 (0.60) | TMEM97SIGMAR1NAAAL3MBTL1CA2 | |
| SCHEMBL5048884 | 0.76 | NAAA (0.55) | TMEM97SIGMAR1NAAAL3MBTL1HDAC3 | |
| SCHEMBL6726058 | 0.76 | NAAA (0.46) | NAAAPTPN1SIRT3EYA3L3MBTL1 | |
| SCHEMBL31314643 | 0.75 | EYA3 (0.72) | PTPN1SIRT3EYA3NR1H4THRA | |
| SCHEMBL5044268 | 0.74 | NAAA (0.60) | TMEM97SIGMAR1NAAAL3MBTL1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |