Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC29A1 | Q99808 | 11/20 | 0.63 |
| ▸ | STAT6 | P42226 | 1/20 | 0.63 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.57 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.57 |
| ▸ | THPO | P40225 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5037015 | 0.80 | SLC29A1 (0.62) | SLC29A1STAT6ADORA3ADORA2AADORA1 | |
| 6-Benzylthioinosine SCHEMBL15427008 | 0.78 | SLC29A1 (1.00) | SLC29A1STAT6 | |
| 6-Benzylthioinosine SCHEMBL7617372 | 0.78 | SLC29A1 (1.00) | SLC29A1STAT6 | |
| 6-Benzylthioinosine SCHEMBL3676029 | 0.78 | SLC29A1 (1.00) | SLC29A1STAT6 | |
| 6-Benzylthioinosine SCHEMBL7617380 | 0.78 | SLC29A1 (1.00) | SLC29A1STAT6 | |
| SCHEMBL5044909 | 0.77 | SLC29A1 (0.91) | SLC29A1STAT6ADORA3ADORA2AADORA1 | |
| SCHEMBL9350374 | 0.75 | SLC29A1 (0.74) | SLC29A1STAT6ADORA3ADORA2AADORA1 | |
| SCHEMBL9347373 | 0.75 | SLC29A1 (0.74) | SLC29A1STAT6ADORA3ADORA2AADORA1 | |
| SCHEMBL8500982 | 0.74 | SLC29A1 (0.78) | SLC29A1STAT6ADORA3ADORA2AADORA1 | |
| SCHEMBL17824407 | 0.73 | SLC29A1 (0.73) | SLC29A1STAT6ADORA3ADORA2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492803-B1 | NEW ANALOGS OF NITROBENZYLTHIOINOSINE | GRUENENTHAL GMBH (DE) | 2008-06-11 | — | — | EP | claimed |
| US-7358235-B2 | Analogs of nitrobenzylthioinosine | GRUENENTHAL GMBH (DE) | 2008-04-15 | — | — | US | claimed |
| JP-2005526106-A | — | — | 2005-09-02 | — | — | JP | claimed |
| US-20050096293-A1 | Analogs of nitrobenzylthioinosine | GRUENENTHAL GMBH (DE) | 2005-05-05 | — | — | US | claimed |
| EP-1492803-A1 | NEW ANALOGS OF NITROBENZYLTHIOINOSINE | Grünenthal GmbH (DE) | 2005-01-05 | — | — | EP | claimed |
| WO-2003084975-A1 | NEW ANALOGS OF NITROBENZYLTHIOINOSINE | Grünenthal GmbH (DE) | 2003-10-16 | — | — | WO | claimed |
| EP-1352910-A1 | New analogs of nitrobenzylthioinosine | Grünenthal GmbH (DE) | 2003-10-15 | — | — | EP | claimed |
| EP-1492803-B1 | NEW ANALOGS OF NITROBENZYLTHIOINOSINE | GRUENENTHAL GMBH (DE) | 2008-06-11 | — | — | EP | disclosed |
| US-7358235-B2 | Analogs of nitrobenzylthioinosine | GRUENENTHAL GMBH (DE) | 2008-04-15 | — | — | US | disclosed |
| US-20050096293-A1 | Analogs of nitrobenzylthioinosine | GRUENENTHAL GMBH (DE) | 2005-05-05 | — | — | US | disclosed |
| EP-1492803-A1 | NEW ANALOGS OF NITROBENZYLTHIOINOSINE | Grünenthal GmbH (DE) | 2005-01-05 | — | — | EP | disclosed |
| WO-2003084975-A1 | NEW ANALOGS OF NITROBENZYLTHIOINOSINE | Grünenthal GmbH (DE) | 2003-10-16 | — | — | WO | disclosed |
| EP-1352910-A1 | New analogs of nitrobenzylthioinosine | Grünenthal GmbH (DE) | 2003-10-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050096293-A1 | Analogs of nitrobenzylthioinosine | NUDT1, TYMP, NNMT | SLC29A1 159/4885STAT6 3133/4885ADORA3 1509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.