Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.37 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | IGLV6-57 | P01721 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | GSR | P00390 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | CASR | P41180 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5322356 | 0.79 | GABBR2 (0.43) | KMT2ACYP2D6 | |
| SCHEMBL1357121 | 0.79 | LMNA (0.43) | LMNAALDH1A1HTTKMT2AIGLV6-57 | |
| SCHEMBL3408278 | 0.78 | LMNA (0.46) | LMNAALDH1A1HTTMIFPOLB | |
| SCHEMBL27389987 | 0.78 | LMNA (0.46) | LMNAALDH1A1HTTMIFPOLB | |
| SCHEMBL1827511 | 0.77 | LMNA (0.42) | LMNAALDH1A1HTTMIFALKBH1 | |
| SCHEMBL13616887 | 0.77 | LMNA (0.42) | LMNAALDH1A1HTTMIFALKBH1 | |
| SCHEMBL2322250 | 0.77 | HCAR2 (0.43) | HTTKMT2AMEN1HCAR2CYP2D6 | |
| SCHEMBL16416740 | 0.76 | CYP2D6 (0.44) | LMNAALDH1A1KMT2AGSRMEN1 | |
| SCHEMBL11363032 | 0.76 | LMNA (0.41) | LMNAALDH1A1HTTKMT2AIGLV6-57 | |
| SCHEMBL4871158 | 0.75 | LMNA (0.43) | LMNAALDH1A1HTTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1677745-A4 | NITRONE COMPOUNDS PRODRUGS AND PHARMACEUTICAL COMPOSITIONS OF THE SAME TO TREAT HUMAN DISORDERS | RENOVIS INC (US) | 2008-10-22 | — | — | EP | disclosed |
| EP-1677745-A2 | NITRONE COMPOUNDS PRODRUGS AND PHARMACEUTICAL COMPOSITIONS OF THE SAME TO TREAT HUMAN DISORDERS | Renovis, Inc. (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005037208-A2 | NITRONE COMPOUNDS PRODRUGS AND PHARMACEUTICAL COMPOSITIONS OF THE SAME TO TREAT HUMAN DISORDERS | RENOVIS, INC. (US) | 2005-04-28 | — | — | WO | disclosed |
| EP-1465897-A2 | PROCESS FOR PREPARING PROTEASE INHIBITOR INTERMEDIATES | SmithKline Beecham Corporation (US) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003024974-A2 | PROCESS FOR PREPARING PROTEASE INHIBITOR INTERMEDIATES | SMITHKLINE BEECHAM CORPORATION (US) | 2003-03-27 | — | — | WO | disclosed |