Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 10/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5040886 | 1.00 | ENPP2 (0.42) | ENPP2SLC6A9KCNH2PDE10AEPHX2 | |
| SCHEMBL5043083 | 0.87 | F10 (0.39) | ENPP2KCNH2F10DGAT2MGLL | |
| SCHEMBL5045512 | 0.87 | F10 (0.39) | ENPP2KCNH2F10DGAT2MGLL | |
| SCHEMBL5043572 | 0.85 | DGAT2 (0.39) | TRPV1DGAT2 | |
| SCHEMBL5043577 | 0.85 | DGAT2 (0.39) | TRPV1DGAT2 | |
| SCHEMBL5044097 | 0.83 | P2RX7 (0.44) | ENPP2KCNH2EPHX2TRPV1DGAT2 | |
| SCHEMBL5044099 | 0.83 | P2RX7 (0.44) | ENPP2KCNH2EPHX2TRPV1DGAT2 | |
| Hydrochloric Acid SCHEMBL6068477 | 0.82 | F10 (0.53) | PDE10AEPHX2TRPV1F10 | |
| Hydrochloric Acid SCHEMBL5041206 | 0.82 | F10 (0.53) | PDE10AEPHX2TRPV1F10 | |
| SCHEMBL5045474 | 0.81 | F10 (0.45) | ENPP2TRPV1F10DGAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567498-B1 | MANDELIC ACID DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-01-23 | — | — | EP | disclosed |
| US-7129238-B2 | Mandelic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 2006-10-31 | — | — | US | disclosed |
| EP-1567498-A2 | MANDELIC ACID DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-08-31 | — | — | EP | disclosed |
| US-20040122057-A1 | Novel mandelic acid derivatives | HOFFMANN-LA ROCHE INC. | 2004-06-24 | — | — | US | disclosed |
| WO-2004048335-A2 | MANDELIC ACID DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040122057-A1 | Novel mandelic acid derivatives | F7, F11, F9 | ENPP2 696/4885SLC6A9 1529/4885KCNH2 4519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.