Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.41 |
| ▸ | FABP4 | P15090 | 2/20 | 0.41 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5037704 | 0.90 | KAT2B (0.46) | MAPK1L3MBTL1ALDH1A1KMT2APDE4A | |
| SCHEMBL5045483 | 0.86 | FABP4 (0.43) | MAPK1L3MBTL1KMT2AFABP4FABP5 | |
| SCHEMBL2825503 | 0.84 | FABP4 (0.45) | MAPK1L3MBTL1ALDH1A1FABP4FABP5 | |
| SCHEMBL2824807 | 0.82 | SLC6A9 (0.51) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5043148 | 0.81 | MAPK1 (0.49) | MAPK1L3MBTL1ALDH1A1LMNARAB9A | |
| SCHEMBL11460936 | 0.81 | MAPK1 (0.69) | MAPK1L3MBTL1ALDH1A1KMT2ALMNA | |
| SCHEMBL1811462 | 0.80 | SLC6A9 (0.51) | KMT2ALMNAFABP4FABP5PDE4A | |
| SCHEMBL2826409 | 0.79 | SLC6A9 (0.52) | KMT2ALMNAFABP4FABP5PDE4A | |
| SCHEMBL5037977 | 0.79 | APEX1 (0.42) | FABP4FABP5PDE4APDE4BPDE4C | |
| SCHEMBL5041669 | 0.76 | KAT2B (0.52) | MAPK1PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656361-B1 | PIPERAZINE WITH OR-SUBSTITUTED PHENYL GROUP AND THEIR USE AS GLYT1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |