Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 2/20 | 0.52 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.42 |
| ▸ | IDH2 | P48735 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.41 |
| ▸ | PDE4A | P27815 | 3/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5045483 | 0.89 | FABP4 (0.43) | SYKTSHRSLC6A9PDE4DPDE4A | |
| SCHEMBL2825503 | 0.89 | FABP4 (0.45) | SYKTSHRPDE4DPDE4APDE4B | |
| SCHEMBL5037704 | 0.87 | KAT2B (0.46) | KAT2BBAZ2BSYKTSHRSLC6A9 | |
| SCHEMBL4424161 | 0.86 | SLC6A9 (0.53) | KAT2BBAZ2BSYKSLC6A9PDE4D | |
| SCHEMBL15144072 | 0.80 | BRD4 (0.49) | KAT2BBAZ2BSYKSLC6A9PDE4D | |
| SCHEMBL2830062 | 0.78 | YAP1 (0.48) | PDE4DPDE4APDE4BPDE4CGAA | |
| SCHEMBL3878089 | 0.76 | MAPK1 (0.62) | TSHRMAPK1APEX1 | |
| SCHEMBL5042130 | 0.76 | SLC6A9 (0.66) | SLC6A9GAA | |
| SCHEMBL5041727 | 0.76 | MAPK1 (0.48) | TSHRPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL25314851 | 0.76 | KAT2B (0.50) | KAT2BBAZ2BSYKPDE4DPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656361-B1 | PIPERAZINE WITH OR-SUBSTITUTED PHENYL GROUP AND THEIR USE AS GLYT1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |