Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
| ▸ | FABP4 | P15090 | 2/20 | 0.42 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.40 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5037977 | 0.97 | APEX1 (0.42) | PDE4APDE4BPDE4CPDE4DFABP4 | |
| SCHEMBL1811462 | 0.85 | SLC6A9 (0.51) | PDE4APDE4BPDE4CPDE4DFABP4 | |
| SCHEMBL2826409 | 0.84 | SLC6A9 (0.52) | PDE4APDE4BPDE4CPDE4DFABP4 | |
| SCHEMBL2824807 | 0.82 | SLC6A9 (0.51) | PDE4APDE4BPDE4CPDE4DAPEX1 | |
| SCHEMBL2825503 | 0.82 | FABP4 (0.45) | PDE4APDE4BPDE4CPDE4DFABP4 | |
| SCHEMBL5045483 | 0.79 | FABP4 (0.43) | PDE4APDE4BPDE4CPDE4DFABP4 | |
| SCHEMBL4422191 | 0.78 | APEX1 (0.44) | APEX1MRGPRX1SLC6A9 | |
| SCHEMBL5043956 | 0.77 | SLC6A9 (0.45) | PDE4APDE4BPDE4CPDE4DFABP4 | |
| SCHEMBL8962289 | 0.77 | GAA (0.47) | APEX1GAAKMT2A | |
| SCHEMBL4424161 | 0.76 | SLC6A9 (0.53) | PDE4APDE4BPDE4CPDE4DAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656361-B1 | PIPERAZINE WITH OR-SUBSTITUTED PHENYL GROUP AND THEIR USE AS GLYT1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |