Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 2/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5035220 | 0.90 | KMO (0.40) | NISCHKMODPP4MGAMGAA | |
| SCHEMBL2560329 | 0.73 | ERN1 (0.43) | NISCHKMOMGAMGAASI | |
| SCHEMBL600053 | 0.72 | TAAR1 (0.50) | DPP4MGAMGAASIMGAM2 | |
| SCHEMBL6596072 | 0.71 | KMT2A (0.40) | NISCHDPP4GAATAAR1MAPT | |
| Hydrochloric Acid SCHEMBL7340468 | 0.69 | KMT2A (0.39) | NISCHDPP4GAATAAR1MAPT | |
| SCHEMBL4790256 | 0.69 | LOXL2 (0.39) | GAAPDE3BPDE3AMAPTKDM4E | |
| SCHEMBL28128066 | 0.69 | MAOB (0.44) | TAAR1KDM4ENPC1ALDH1A1PKM | |
| SCHEMBL7159559 | 0.69 | ALDH1A1 (0.47) | GAAERN1MAPTKDM4ENPC1 | |
| SCHEMBL7162384 | 0.68 | GRIN2B (0.38) | KCNH2GRIN2B | |
| Hydroxyamine SCHEMBL7338060 | 0.67 | KMT2A (0.37) | NISCHDPP4GAATAAR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1680420-A4 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS INC (US) | 2008-09-24 | — | — | EP | disclosed |
| EP-1680420-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2006-07-19 | — | — | EP | disclosed |
| WO-2005046588-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2005-05-26 | — | — | WO | disclosed |