Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7159598 | 0.83 | KMO (0.45) | ALDH1A1PDGFRBPDGFRAKDM4EGAA | |
| SCHEMBL7161302 | 0.81 | KMO (0.43) | ALDH1A1MEN1KMT2APDGFRBPDGFRA | |
| SCHEMBL15329643 | 0.77 | ERN1 (0.47) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL7422530 | 0.76 | PDE4A (0.53) | — | |
| SCHEMBL10556612 | 0.76 | KDM4E (0.46) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL7140253 | 0.76 | NPC1 (0.51) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL7158317 | 0.76 | KIF11 (0.54) | — | |
| SCHEMBL24785816 | 0.75 | NPC1 (0.47) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL30103021 | 0.75 | NPC1 (0.47) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL7144909 | 0.75 | ALDH1A1 (0.50) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358165-A1 | IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002060877-A1 | IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-08 | — | — | WO | disclosed |