Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | CPA1 | P15085 | 1/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GPR132 | Q9UNW8 | 3/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5042694 | 0.90 | MME (0.43) | MMEACECPA1ACE2ALDH1A1 | |
| SCHEMBL3902883 | 0.83 | MME (0.56) | MMEACECPA1ACE2ALDH1A1 | |
| SCHEMBL5046992 | 0.77 | GPR132 (0.42) | MMEACECPA1ACE2ALDH1A1 | |
| SCHEMBL21964974 | 0.76 | ALDH1A1 (0.51) | MMEACECPA1ACE2ALDH1A1 | |
| SCHEMBL5041097 | 0.76 | MME (0.42) | MMEACECPA1ACE2ALDH1A1 | |
| SCHEMBL5139716 | 0.75 | ALDH1A1 (0.52) | MMEACECPA1ACE2ALDH1A1 | |
| SCHEMBL5047012 | 0.74 | GPR132 (0.43) | MMEACECPA1ACE2ALDH1A1 | |
| SCHEMBL4064892 | 0.74 | CTBP2 (0.54) | ALDH1A1GPR132POLBRAB9A | |
| SCHEMBL5041103 | 0.74 | MME (0.43) | MMEACECPA1ACE2ALDH1A1 | |
| SCHEMBL5040970 | 0.73 | FAAH (0.41) | MMEACECPA1ACE2GPR132 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654260-A4 | 6-MENBERED HETEROARYL COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER PROD INC (US) | 2008-09-24 | — | — | EP | disclosed |
| EP-1654260-A2 | 6-MENBERED HETEROARYL COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | Pfizer Products Inc. (US) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005011601-A2 | 6-MENBERED HETEROARYL COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER PRODUCTS, INC. (US) | 2005-02-10 | — | — | WO | disclosed |