Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | DHFR | P00374 | 2/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PHGDH | O43175 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10373770 | 0.90 | ADRB1 (0.74) | ADRB1KCNH2ALDH1A1MAPTRAB9A | |
| SCHEMBL11103700 | 0.90 | ADRB1 (0.74) | ADRB1KCNH2ALDH1A1MAPTRAB9A | |
| SCHEMBL11096302 | 0.84 | KCNH2 (0.73) | ADRB1KCNH2ALDH1A1MAPTRAB9A | |
| SCHEMBL7924167 | 0.82 | KCNH2 (0.67) | ADRB1KCNH2ALDH1A1MAPTRAB9A | |
| SCHEMBL8264176 | 0.82 | ADRB1 (0.69) | ADRB1KCNH2ALDH1A1MAPTRAB9A | |
| SCHEMBL12991 | 0.82 | ADRB1 (0.69) | ADRB1KCNH2ALDH1A1MAPTRAB9A | |
| SCHEMBL11211650 | 0.81 | ADRB1 (0.62) | ADRB1KCNH2ALDH1A1MAPTRAB9A | |
| SCHEMBL3307690 | 0.80 | ADRB1 (0.67) | ADRB1KCNH2ALDH1A1MAPTRAB9A | |
| SCHEMBL17281442 | 0.80 | ADRB1 (0.67) | ADRB1KCNH2ALDH1A1MAPTRAB9A | |
| Hydrochloric Acid SCHEMBL27827352 | 0.80 | ADRB1 (0.67) | ADRB1KCNH2ALDH1A1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622569-A4 | AZA SPIRO ALKANE DERIVATIVES AS INHIBITORS OF METALLPROTEASES | INCYTE CORP (US) | 2008-08-27 | — | — | EP | disclosed |
| EP-1622569-A2 | AZA SPIRO ALKANE DERIVATIVES AS INHIBITORS OF METALLPROTEASES | Incyte Corporation (US) | 2006-02-08 | — | — | EP | disclosed |
| WO-2004096139-A2 | AZA SPIRO ALKANE DERIVATIVES AS INHIBITORS OF METALLOPROTEASES | INCYTE CORPORATION (US) | 2004-11-11 | — | — | WO | disclosed |