Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 20/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5778487 | 0.91 | CRHR1 (0.34) | CRHR1 | |
| Trifluoroacetic Acid SCHEMBL5047023 | 0.81 | CRHR1 (0.34) | CRHR1 | |
| Trifluoroacetic Acid SCHEMBL5039343 | 0.79 | CRHR1 (0.32) | CRHR1 | |
| Trifluoroacetic Acid SCHEMBL5044805 | 0.78 | MEN1 (0.39) | CRHR1 | |
| SCHEMBL5043423 | 0.74 | CRHR1 (0.32) | CRHR1 | |
| Trifluoroacetic Acid SCHEMBL5045505 | 0.74 | KDM4E (0.40) | — | |
| Trifluoroacetic Acid SCHEMBL4702931 | 0.73 | CRHR1 (0.36) | CRHR1 | |
| Trifluoroacetic Acid SCHEMBL5044836 | 0.72 | CRHR1 (0.36) | CRHR1 | |
| SCHEMBL5044224 | 0.70 | CRHR1 (0.30) | CRHR1 | |
| SCHEMBL6022722 | 0.70 | CRHR1 (0.34) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432283-B2 | Heterocyclic GABAA subtype selective receptor modulators | ROCHE PALO ALTO LLC (US) | 2008-10-07 | — | — | US | disclosed |
| US-7268146-B2 | Ring fused pyrazole derivatives as CRF antagonists | PALO ALTO LLC (US) | 2007-09-11 | — | — | US | disclosed |
| US-7053103-B2 | Ring fused pyrazole derivatives as CRF antagonists | SYNTEX (U.S.A.) LLC (US) | 2006-05-30 | — | — | US | disclosed |