Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5776560 | 0.92 | KDM4E (0.42) | KDM4ETDP1MEN1KMT2AL3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL5044805 | 0.88 | MEN1 (0.39) | KDM4EMEN1KMT2APOLBHDAC3 | |
| Trifluoroacetic Acid SCHEMBL5039343 | 0.84 | CRHR1 (0.32) | KDM4ETDP1MEN1KMT2AL3MBTL1 | |
| SCHEMBL5776118 | 0.78 | SMN1; SMN2 (0.35) | KDM4ETDP1MEN1KMT2AL3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL4699604 | 0.77 | KDM4E (0.44) | KDM4ETDP1MEN1KMT2APOLB | |
| Trifluoroacetic Acid SCHEMBL5043695 | 0.76 | HTT (0.34) | MEN1KMT2APOLB | |
| SCHEMBL5776900 | 0.75 | MEN1 (0.32) | MEN1KMT2AL3MBTL1 | |
| SCHEMBL5522195 | 0.74 | CRHR1 (0.33) | — | |
| Trifluoroacetic Acid SCHEMBL5043920 | 0.74 | CRHR1 (0.36) | — | |
| Trifluoroacetic Acid SCHEMBL5039148 | 0.69 | PKM (0.33) | MEN1KMT2APOLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432283-B2 | Heterocyclic GABAA subtype selective receptor modulators | ROCHE PALO ALTO LLC (US) | 2008-10-07 | — | — | US | disclosed |
| US-7268146-B2 | Ring fused pyrazole derivatives as CRF antagonists | PALO ALTO LLC (US) | 2007-09-11 | — | — | US | disclosed |
| US-7053103-B2 | Ring fused pyrazole derivatives as CRF antagonists | SYNTEX (U.S.A.) LLC (US) | 2006-05-30 | — | — | US | disclosed |