Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | LSS | P48449 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | EYA3 | Q99504 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1851704 | 0.89 | LSS (0.46) | MAPK14LSSPTPN1EPHX2PPARG | |
| SCHEMBL5044446 | 0.87 | PPARG (0.45) | MAPK14LSSPTPN1EPHX2PPARG | |
| SCHEMBL1855758 | 0.86 | LSS (0.44) | MAPK14LSSPTPN1EPHX2PPARG | |
| SCHEMBL1860426 | 0.85 | HDAC3 (0.50) | PTPN1EYA3HDAC3HDAC1HDAC2 | |
| SCHEMBL6022117 | 0.82 | PTPN1 (0.51) | PTPN1EYA3HDAC3HDAC1HDAC2 | |
| SCHEMBL1854032 | 0.82 | LSS (0.41) | MAPK14LSSPTPN1EPHX2PPARG | |
| SCHEMBL1853826 | 0.73 | MLYCD (0.64) | LSSEPHX2PPARGPPARAHDAC3 | |
| SCHEMBL5040035 | 0.72 | TMEM97 (0.48) | PTPN1EYA3HDAC3HDAC1HDAC2 | |
| SCHEMBL1856867 | 0.71 | TMEM97 (0.50) | PTPN1EYA3HDAC3HDAC1HDAC2 | |
| SCHEMBL6022102 | 0.71 | LSS (0.47) | MAPK14LSSEPHX2PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |