Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 7/20 | 0.51 |
| ▸ | EYA3 | Q99504 | 2/20 | 0.51 |
| ▸ | SIRT3 | Q9NTG7 | 5/20 | 0.46 |
| ▸ | TTR | P02766 | 1/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | KDM5A | P29375 | 1/20 | 0.42 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5044450 | 0.82 | MAPK14 (0.47) | PTPN1EYA3SIRT3NR1H4HDAC3 | |
| SCHEMBL1860426 | 0.79 | HDAC3 (0.50) | PTPN1EYA3SIRT3NR1H4HDAC3 | |
| SCHEMBL5044446 | 0.77 | PPARG (0.45) | PTPN1EYA3 | |
| SCHEMBL1851704 | 0.77 | LSS (0.46) | PTPN1EYA3NR1H4HDAC3HDAC1 | |
| SCHEMBL1855758 | 0.75 | LSS (0.44) | PTPN1EYA3NR1H4 | |
| SCHEMBL31314643 | 0.75 | EYA3 (0.72) | PTPN1EYA3SIRT3TTRTHRA | |
| SCHEMBL5040035 | 0.74 | TMEM97 (0.48) | PTPN1EYA3SIRT3THRATHRB | |
| SCHEMBL8810393 | 0.72 | PTPN1 (0.61) | PTPN1EYA3TTRTHRATHRB | |
| Acetic Acid SCHEMBL27738439 | 0.72 | TMEM97 (0.48) | PTPN1EYA3SIRT3NR1H4HDAC3 | |
| Hydrochloric Acid SCHEMBL8732680 | 0.71 | PTPN1 (0.60) | PTPN1EYA3TTRTHRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1933827-A | Use of methylene amide derivatives in cardiovascular disorders | APPLIED RESEARCH SYSTEMS (AN) | 2007-03-21 | — | — | CN | claimed |
| EP-1732534-A1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | Applied Research Systems ARS Holding N.V. (AN) | 2006-12-20 | — | — | EP | claimed |
| WO-2005082347-A1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | APLLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2005-09-09 | — | — | WO | claimed |
| CN-1933827-B | Use of methylene amide derivatives in preparing medicine for treating and/ or preventing heart failure | SERONO LAB | 2011-07-27 | — | — | CN | disclosed |
| CN-1933827-A | Use of methylene amide derivatives in cardiovascular disorders | APPLIED RESEARCH SYSTEMS (AN) | 2007-03-21 | — | — | CN | disclosed |