Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RORC | P51449 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1860786 | 0.88 | PPARG (0.46) | PPARGEPHX2ALDH1A1LMNARORC | |
| SCHEMBL5044609 | 0.88 | EPHX2 (0.52) | PPARGEPHX2ALDH1A1TRPV1HPGD | |
| SCHEMBL5044633 | 0.84 | PPARG (0.45) | PPARGEPHX2ALDH1A1LMNARORC | |
| SCHEMBL1860265 | 0.82 | PPARG (0.44) | PPARGEPHX2ALDH1A1LMNARORC | |
| SCHEMBL5048757 | 0.81 | PPARG (0.44) | PPARGEPHX2ALDH1A1LMNARORC | |
| SCHEMBL5044608 | 0.81 | EPHX2 (0.49) | PPARGEPHX2ALDH1A1LMNATRPV1 | |
| SCHEMBL5040011 | 0.79 | FFAR1 (0.48) | ALDH1A1LMNAL3MBTL1TRPV1HPGD | |
| SCHEMBL5044219 | 0.78 | MLYCD (0.48) | PPARGEPHX2ALDH1A1L3MBTL1TRPV1 | |
| SCHEMBL1853096 | 0.78 | ALDH1A1 (0.46) | PPARGEPHX2ALDH1A1TRPV1HPGD | |
| SCHEMBL4330881 | 0.77 | MAPK14 (0.47) | PPARGEPHX2ALDH1A1LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |