Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | NAAA | Q02083 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | KIFC1 | Q9BW19 | 6/20 | 0.42 |
| ▸ | MLYCD | O95822 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5047162 | 1.00 | HDAC1 (0.44) | HDAC1HDAC2NAAAALDH1A1POLB | |
| SCHEMBL1852984 | 0.90 | MLYCD (0.51) | NAAAALDH1A1MLYCDSMN1; SMN2EPHX2 | |
| SCHEMBL1853396 | 0.85 | MLYCD (0.47) | NAAAALDH1A1POLBMRGPRX4MLYCD | |
| SCHEMBL5045562 | 0.85 | ALDH1A1 (0.47) | HDAC1HDAC2NAAAALDH1A1POLB | |
| SCHEMBL5044168 | 0.85 | ALDH1A1 (0.47) | HDAC1HDAC2NAAAALDH1A1POLB | |
| SCHEMBL5039508 | 0.82 | ROCK2 (0.44) | HDAC1NAAAKIFC1MLYCDPTGS2 | |
| SCHEMBL1861375 | 0.80 | NAAA (0.48) | HDAC1HDAC2NAAAALDH1A1POLB | |
| SCHEMBL1857017 | 0.80 | NAAA (0.48) | HDAC1HDAC2NAAAALDH1A1POLB | |
| SCHEMBL5046973 | 0.78 | UTS2R (0.47) | SMN1; SMN2EPHX2PPARGPPARAMME | |
| SCHEMBL4978882 | 0.78 | PLK1 (0.47) | HDAC1SMN1; SMN2PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | disclosed |