Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.52 |
| ▸ | CA1 | P00915 | 3/20 | 0.52 |
| ▸ | CA2 | P00918 | 3/20 | 0.52 |
| ▸ | CA9 | Q16790 | 3/20 | 0.52 |
| ▸ | SCN10A | Q9Y5Y9 | 6/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5041227 | 0.91 | RXFP1 (0.48) | CA12CA1CA2CA9SCN10A | |
| SCHEMBL5048256 | 0.88 | CA2 (0.55) | CA12CA1CA2CA9 | |
| SCHEMBL5035282 | 0.85 | CA2 (0.46) | CA12CA1CA2CA9SCN10A | |
| SCHEMBL5041321 | 0.85 | CA12 (0.56) | CA12CA1CA2CA9SCN10A | |
| SCHEMBL5048263 | 0.84 | CA12 (0.53) | CA12CA1CA2CA9SCN10A | |
| SCHEMBL5048467 | 0.84 | MAPK1 (0.64) | CA12CA1CA2CA9 | |
| SCHEMBL5049394 | 0.82 | CA12 (0.50) | CA12CA1CA2CA9SCN10A | |
| SCHEMBL5045051 | 0.79 | NPC1 (0.50) | CA12CA1CA2CA9SCN10A | |
| SCHEMBL5046705 | 0.78 | CA2 (0.54) | CA12CA1CA2CA9 | |
| SCHEMBL5041539 | 0.77 | NTRK1 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7378417-B2 | Pyrazolo-pyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-05-27 | — | — | US | claimed |
| US-20050282827-A1 | Pyrazolo-pyrimidine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | US | claimed |
| US-7378417-B2 | Pyrazolo-pyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-05-27 | — | — | US | disclosed |
| US-20050282827-A1 | Pyrazolo-pyrimidine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050282827-A1 | Pyrazolo-pyrimidine derivatives | P2RX3, P2RX1, P2RX5 | CA12 4779/4885CA1 4019/4885CA2 3957/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.