Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | PPARA | Q07869 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.39 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5044895 | 0.91 | EPHX2 (0.48) | HTR2CEPHX2PPARGPPARANR1H4 | |
| SCHEMBL5045752 | 0.87 | EPHX2 (0.42) | HTR2CEPHX2PPARGPPARAMAPK14 | |
| SCHEMBL6023308 | 0.83 | MAPK14 (0.51) | HTR2CEPHX2PPARGPPARAMAPK14 | |
| SCHEMBL6022101 | 0.83 | PPARG (0.46) | EPHX2PPARGPPARAMAPK14TRPV1 | |
| SCHEMBL6023237 | 0.81 | EPHX2 (0.49) | HTR2CEPHX2PPARGPPARANR1H4 | |
| SCHEMBL5047681 | 0.80 | DDR1 (0.43) | HTR2CEPHX2PPARGPPARAMAPK14 | |
| SCHEMBL5044898 | 0.80 | EPHX2 (0.51) | HTR2CEPHX2PPARGPPARANR1H4 | |
| SCHEMBL1861388 | 0.79 | MAPK14 (0.47) | HTR2CEPHX2PPARGPPARAMAPK14 | |
| SCHEMBL5044228 | 0.77 | NAMPT (0.46) | DDR1GPR139TRPV1NAMPT | |
| SCHEMBL5044633 | 0.76 | PPARG (0.45) | HTR2CEPHX2PPARGPPARANR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-A1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | Applied Research Systems ARS Holding N.V. (AN) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005082347-A1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | APLLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2005-09-09 | — | — | WO | disclosed |