Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | NAAA | Q02083 | 1/20 | 0.40 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.39 |
| ▸ | MLYCD | O95822 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGAV | P06756 | 1/20 | 0.37 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.37 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5045752 | 0.88 | EPHX2 (0.42) | GPR139DDR1MAPK14HPGDTRPV1 | |
| SCHEMBL5039508 | 0.85 | ROCK2 (0.44) | GPR139NAMPTHDAC1HDAC3NAAA | |
| SCHEMBL5047987 | 0.83 | PTGS2 (0.41) | HDAC1NAAAPTGS2MEN1LMNA | |
| SCHEMBL5044228 | 0.80 | NAMPT (0.46) | GPR139NAMPTHDAC1HDAC3NAAA | |
| SCHEMBL5047681 | 0.80 | DDR1 (0.43) | GPR139DDR1MAPK14LMNAHPGD | |
| SCHEMBL5045260 | 0.79 | NAMPT (0.46) | NAMPTHDAC1HDAC3NAAADDR1 | |
| SCHEMBL6022126 | 0.79 | ALDH1A1 (0.46) | GPR139NAMPTHDAC1HDAC3NAAA | |
| SCHEMBL5045263 | 0.77 | MAPK14 (0.48) | NAMPTHDAC1HDAC3NAAADDR1 | |
| SCHEMBL1851514 | 0.77 | NAMPT (0.43) | NAMPTHDAC1HDAC3NAAADDR1 | |
| SCHEMBL1853396 | 0.75 | MLYCD (0.47) | GPR139NAAAMLYCDLMNAGCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-A1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | Applied Research Systems ARS Holding N.V. (AN) | 2006-12-20 | — | — | EP | claimed |
| WO-2005082347-A1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | APLLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2005-09-09 | — | — | WO | claimed |