Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 2/20 | 0.52 |
| ▸ | NAMPT | P43490 | 2/20 | 0.46 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GPR183 | P32249 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7768094 | 0.99 | LSS (0.53) | LSSNAMPTL3MBTL3L3MBTL1KMT2A | |
| SCHEMBL27499031 | 0.85 | LSS (0.39) | LSSNAMPTL3MBTL1POLBMGLL | |
| SCHEMBL7768101 | 0.85 | ALDH1A1 (0.41) | LSSKMT2ALMNAALDH1A1 | |
| SCHEMBL27578406 | 0.79 | LSS (0.39) | LSSHPGDLMNAALDH1A1 | |
| SCHEMBL27578407 | 0.79 | LSS (0.39) | LSSHPGDLMNAALDH1A1 | |
| SCHEMBL27500251 | 0.79 | LSS (0.40) | LSSNAMPTKMT2A | |
| SCHEMBL5045824 | 0.79 | LSS (0.80) | LSSKMT2A | |
| SCHEMBL27596324 | 0.79 | LSS (0.40) | LSSHPGDLMNA | |
| SCHEMBL27596322 | 0.79 | LSS (0.40) | LSSHPGDLMNA | |
| SCHEMBL27596279 | 0.79 | LSS (0.40) | LSSHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317432-B1 | PIPERIDINE DERIVATIVES FOR USE AS 2,3-OXIDOSQUALENE-LANOSTEROL CYCLASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-01-16 | — | — | EP | disclosed |