Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOB | P04114 | 2/20 | 0.51 |
| ▸ | MTTP | P55157 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | IDH2 | P48735 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | HPGD | P15428 | 6/20 | 0.46 |
| ▸ | CASP1 | P29466 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | CASP7 | P55210 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5045812 | 0.93 | HSD17B10 (0.49) | MAPK1HSD17B10MAPTTSHRNPSR1 | |
| SCHEMBL5047041 | 0.91 | MAPK1 (0.61) | APOBMTTPMAPK1HSD17B10MAPT | |
| SCHEMBL5041985 | 0.90 | HSD17B10 (0.48) | APOBMTTPMAPK1HSD17B10MAPT | |
| SCHEMBL5045122 | 0.89 | ALDH1A1 (0.48) | MAPK1HSD17B10MAPTTSHRNPSR1 | |
| SCHEMBL5046610 | 0.89 | KDM4E (0.56) | MAPK1HSD17B10MAPTTSHRNPSR1 | |
| SCHEMBL5049467 | 0.89 | HSD17B10 (0.52) | MAPK1HSD17B10MAPTTSHRNPSR1 | |
| SCHEMBL5049458 | 0.88 | TSHR (0.48) | MAPK1HSD17B10MAPTTSHRNPSR1 | |
| SCHEMBL5049364 | 0.88 | HSD17B10 (0.54) | MAPK1HSD17B10MAPTTSHRNPSR1 | |
| SCHEMBL5046190 | 0.87 | KIF18A (0.52) | MAPK1HSD17B10MAPTTSHRNPSR1 | |
| SCHEMBL5049493 | 0.87 | HSD17B10 (0.54) | MAPK1HSD17B10MAPTTSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7378417-B2 | Pyrazolo-pyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-05-27 | — | — | US | disclosed |
| US-20050282827-A1 | Pyrazolo-pyrimidine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050282827-A1 | Pyrazolo-pyrimidine derivatives | P2RX3, P2RX1, P2RX5 | APOB 1926/4885MTTP 2837/4885MAPK1 1732/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.