Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.46 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | CFD | P00746 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.39 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5044420 | 0.85 | GPR139 (0.46) | GPR139KAT6ACHRM3S1PR3EPHX2 | |
| SCHEMBL5045075 | 0.82 | P2RX7 (0.46) | KAT6AEPHX2NR1H4 | |
| SCHEMBL1855533 | 0.81 | GPR139 (0.43) | GPR139KAT6ACHRM3S1PR3EPHX2 | |
| SCHEMBL5045301 | 0.81 | GAA (0.46) | CHRM3ALDH1A1 | |
| SCHEMBL5047059 | 0.80 | GPR139 (0.45) | GPR139KAT6ACHRM3S1PR3EPHX2 | |
| SCHEMBL5039647 | 0.80 | TACR1 (0.54) | GPR139EPHX2NR1H4PRMT5 | |
| SCHEMBL5047432 | 0.75 | NR1H4 (0.53) | EPHX2NR1H4ERN1ALDH1A1CFD | |
| SCHEMBL6022596 | 0.72 | F10 (0.49) | GPR139KAT6AALDH1A1CTSLCTSB | |
| SCHEMBL1854412 | 0.71 | NR1H4 (0.48) | EPHX2NR1H4ERN1ALDH1A1CFD | |
| SCHEMBL5044326 | 0.70 | P2RX7 (0.49) | KAT6AEPHX2NR1H4PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |