Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | SUCNR1 | Q9BXA5 | 4/20 | 0.45 |
| ▸ | UTS2R | Q9UKP6 | 4/20 | 0.45 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.42 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP24A1 | Q07973 | 3/20 | 0.42 |
| ▸ | CYP27B1 | O15528 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5039647 | 0.87 | TACR1 (0.54) | EPHX2NR1H4CYP24A1 | |
| SCHEMBL5044326 | 0.85 | P2RX7 (0.49) | P2RX7EPHX2NR1H4SUCNR1UTS2R | |
| SCHEMBL5046285 | 0.82 | GPR139 (0.46) | EPHX2NR1H4KAT6A | |
| SCHEMBL1854789 | 0.81 | UTS2R (0.48) | P2RX7EPHX2NR1H4SUCNR1UTS2R | |
| SCHEMBL5045759 | 0.79 | UTS2R (0.51) | P2RX7EPHX2NR1H4SUCNR1UTS2R | |
| SCHEMBL5047432 | 0.78 | NR1H4 (0.53) | EPHX2NR1H4 | |
| SCHEMBL4315436 | 0.78 | EPHX2 (0.44) | P2RX7EPHX2NR1H4SUCNR1UTS2R | |
| SCHEMBL5043909 | 0.77 | EPHX2 (0.47) | EPHX2NR1H4SCN2ASCN10A | |
| SCHEMBL1854412 | 0.74 | NR1H4 (0.48) | EPHX2NR1H4UTS2R | |
| SCHEMBL5197801 | 0.69 | MAPT (0.51) | EPHX2NR1H4MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |
| EP-1732534-A1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | Applied Research Systems ARS Holding N.V. (AN) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005082347-A1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | APLLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2005-09-09 | — | — | WO | disclosed |