Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1854548 | 0.83 | GAA (0.45) | GAAABCB1HPGDABCG2PTGDR2 | |
| SCHEMBL5046285 | 0.81 | GPR139 (0.46) | CHRM3ALDH1A1 | |
| SCHEMBL5047546 | 0.75 | NPC1 (0.50) | GAAHPGDRAB9ANPC1MAPT | |
| SCHEMBL6022596 | 0.72 | F10 (0.49) | HPGDRAB9AROCK2NPC1KDM4E | |
| SCHEMBL1856432 | 0.72 | F10 (0.47) | GAAHPGDRAB9AMEN1KMT2A | |
| SCHEMBL5044266 | 0.71 | LTA4H (0.48) | PTGDR2RAB9AMEN1KMT2AAKR1C3 | |
| SCHEMBL2773614 | 0.71 | MMP12 (0.60) | GAAABCB1HPGDABCG2HDAC8 | |
| SCHEMBL5048825 | 0.69 | NAMPT (0.50) | GAAROCK2HDAC3MAPTSMN1; SMN2 | |
| SCHEMBL5943847 | 0.69 | HDAC8 (0.78) | HPGDRAB9APARP1MEN1KMT2A | |
| SCHEMBL5047823 | 0.69 | GAA (0.46) | GAARAB9AROCK2NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |