Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.58 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.49 |
| ▸ | F10 | P00742 | 6/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.48 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.47 |
| ▸ | F2 | P00734 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6028187 | 0.89 | TAAR1 (0.54) | LOXL2SLC7A5MEN1KMT2ATAAR1 | |
| SCHEMBL27474494 | 0.87 | LOXL2 (0.58) | LOXL2TPSAB1PRSS1MEN1KMT2A | |
| SCHEMBL12185043 | 0.86 | LOXL2 (0.45) | LOXL2TPSAB1F10PRSS1SLC7A5 | |
| SCHEMBL8802162 | 0.86 | ALDH1A1 (0.47) | LOXL2F10PRSS1SLC7A5F2 | |
| SCHEMBL28497180 | 0.84 | SLC7A5 (0.47) | LOXL2F10PRSS1SLC7A5F2 | |
| SCHEMBL28497181 | 0.84 | SLC7A5 (0.47) | LOXL2F10PRSS1SLC7A5F2 | |
| SCHEMBL14978879 | 0.83 | CYP4F2 (0.44) | LOXL2SLC7A5MEN1KMT2AALDH1A1 | |
| SCHEMBL2496147 | 0.83 | NLRP3 (0.50) | SLC7A5MEN1KMT2AALDH1A1THRB | |
| SCHEMBL2500604 | 0.83 | NLRP3 (0.50) | SLC7A5MEN1KMT2AALDH1A1THRB | |
| SCHEMBL27810401 | 0.83 | NLRP3 (0.50) | SLC7A5MEN1KMT2AALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442702-B2 | Treatment of bone disorders; carboxy derivatives | PFIZER INC. (US) | 2008-10-28 | — | — | US | disclosed |
| EP-1021410-B1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER (US) | 2006-12-27 | — | — | EP | disclosed |
| US-6498172-B1 | (3-(((4-TERT-BUTYL-BENZYL)-(PYRIDINE-3-SULFONYL)-AMINO)-METHYL) -PHENOXY)-ACETIC ACID OR SALT; TREATING SUCH AS OSTEOPOROSIS | PFIZER INC. | 2002-12-24 | — | — | US | disclosed |
| EP-1021410-A1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER INC. (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1999019300-A1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER INC. (US) | 1999-04-22 | — | — | WO | disclosed |