Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 5/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | RBP4 | P02753 | 3/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1176642 | 1.00 | TRPA1 (0.39) | TRPA1SCN5ASCN9AGSK3BRBP4 | |
| Formic Acid SCHEMBL5556201 | 0.96 | TRPA1 (0.36) | TRPA1SCN5ASCN9AGSK3BRBP4 | |
| SCHEMBL12628022 | 0.92 | RBP4 (0.43) | GSK3BRBP4CFTR | |
| SCHEMBL1176036 | 0.92 | RBP4 (0.43) | GSK3BRBP4CFTR | |
| SCHEMBL1177055 | 0.92 | RBP4 (0.43) | GSK3BRBP4CFTR | |
| SCHEMBL1176208 | 0.89 | DYRK1A (0.41) | GSK3BRBP4JAK2JAK1TYK2 | |
| SCHEMBL5039120 | 0.89 | DYRK1A (0.41) | GSK3BRBP4JAK2JAK1TYK2 | |
| Formic Acid SCHEMBL5557691 | 0.89 | RBP4 (0.41) | GSK3BRBP4CFTR | |
| SCHEMBL5043738 | 0.88 | GSK3B (0.43) | GSK3BRBP4 | |
| SCHEMBL1176315 | 0.88 | GSK3B (0.43) | GSK3BRBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7396833-B2 | Indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof | MEMORY PHARMACEUTICALS CORPORATION (US) | 2008-07-08 | — | — | US | claimed |
| EP-1697378-B1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, AND 1,2-BENZISOTHIAZOLES, AND PREPARATION AND USES THEREOF | MEMORY PHARM CORP (US) | 2007-11-21 | — | — | EP | claimed |