Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.47 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 6/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 2/20 | 0.37 |
| ▸ | NOS1 | P29475 | 2/20 | 0.37 |
| ▸ | NOS2 | P35228 | 2/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9202795 | 0.89 | MAOB (0.38) | NOS3NOS1NOS2 | |
| SCHEMBL10661810 | 0.83 | PRSS1 (0.48) | PRSS1PRSS2PRSS3ENPP2TSHR | |
| SCHEMBL10661820 | 0.83 | PRSS1 (0.48) | PRSS1PRSS2PRSS3ENPP2TSHR | |
| SCHEMBL123838 | 0.81 | TSHR (0.61) | PRSS1PRSS2PRSS3ENPP2TSHR | |
| SCHEMBL2811400 | 0.79 | PRSS1 (0.44) | PRSS1PRSS2PRSS3ENPP2TSHR | |
| SCHEMBL3506161 | 0.78 | ENPP2 (0.54) | ENPP2 | |
| SCHEMBL27483739 | 0.78 | PNMT (0.48) | ENPP2MRGPRX4NOS3NOS1NOS2 | |
| SCHEMBL4872736 | 0.78 | XDH (0.50) | PRSS1PRSS2PRSS3ENPP2TSHR | |
| Hydrochloric Acid SCHEMBL14334287 | 0.78 | ENPP2 (0.58) | PRSS1PRSS2PRSS3ENPP2TSHR | |
| SCHEMBL5793223 | 0.76 | TAAR1 (0.52) | CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716150-B1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2008-04-23 | — | — | EP | disclosed |