Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | NMT2 | O60551 | 1/20 | 0.35 |
| ▸ | NMT1 | P30419 | 1/20 | 0.35 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.34 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.34 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.33 |
| ▸ | CCR3 | P51677 | 5/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | FAP | Q12884 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5047701 | 0.81 | FFAR1 (0.47) | HRH3SLC6A4FFAR2 | |
| SCHEMBL5046558 | 0.81 | FFAR1 (0.47) | HRH3SLC6A4FFAR2 | |
| SCHEMBL5045663 | 0.81 | FFAR1 (0.37) | HRH3SLC6A4KDM4EALDH1A1 | |
| SCHEMBL5044417 | 0.81 | FFAR1 (0.47) | HRH3SLC6A4FFAR2 | |
| SCHEMBL4971850 | 0.81 | SIGMAR1 (0.43) | HRH3SLC6A4NMT2NMT1ADAMTS4 | |
| SCHEMBL5044888 | 0.74 | ITGB1 (0.45) | ITGB1ITGA4ALDH1A1 | |
| SCHEMBL1855276 | 0.74 | PTGES (0.41) | SLC6A4NMT2NMT1ADAMTS4ADAMTS5 | |
| SCHEMBL5039923 | 0.68 | ACACB (0.45) | MAOB | |
| SCHEMBL1854030 | 0.68 | MAOB (0.50) | MAOB | |
| SCHEMBL6721342 | 0.67 | MAOB (0.49) | MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |