Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 8/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 8/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30550437 | 0.72 | FBP1 (0.56) | FBP1MAPTMEN1LMNATP53 | |
| SCHEMBL28598764 | 0.71 | FBP1 (0.55) | FBP1MAPTMEN1LMNATP53 | |
| SCHEMBL28604120 | 0.71 | FBP1 (0.55) | FBP1MAPTMEN1LMNATP53 | |
| SCHEMBL28603873 | 0.69 | FBP1 (0.52) | FBP1MAPTMEN1LMNATP53 | |
| SCHEMBL3045939 | 0.68 | CYP3A4 (0.53) | FBP1MAPTMEN1LMNATP53 | |
| SCHEMBL3055747 | 0.68 | CYP3A4 (0.53) | FBP1MAPTMEN1LMNATP53 | |
| Rhodomyrtoxin B SCHEMBL12827333 | 0.67 | MAPT (1.00) | FBP1MAPTMEN1LMNATP53 | |
| SCHEMBL24075664 | 0.65 | HIF1A (0.54) | FBP1HIF1AEPAS1FFAR1PTGES | |
| SCHEMBL31576814 | 0.65 | HIF1A (0.54) | FBP1HIF1AEPAS1FFAR1PTGES | |
| SCHEMBL10000323 | 0.62 | KDM4E (0.45) | FBP1MAPTMEN1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9273021-B2 | Dibenzofuran derivatives as inhibitors of fructose 1,6-bisphosphatase and methods of use thereof | TRUSTEES OF BOSTON COLLEGE (US) | 2016-03-01 | — | — | US | disclosed |
| US-9273021-B2 | Dibenzofuran derivatives as inhibitors of fructose 1,6-bisphosphatase and methods of use thereof | TRUSTEES OF BOSTON COLLEGE (US) | 2016-03-01 | — | — | US | disclosed |
| US-9273021-B2 | Dibenzofuran derivatives as inhibitors of fructose 1,6-bisphosphatase and methods of use thereof | TRUSTEES OF BOSTON COLLEGE (US) | 2016-03-01 | — | — | US | disclosed |
| US-20120028892-A1 | INHIBITORS OF FRUCTOSE 1,6-BISPHOSPHATASE AND METHODS OF USE THEREOF | TRUSTEES OF BOSTON COLLEGE (US) | 2012-02-02 | — | — | US | disclosed |
| US-20120028892-A1 | INHIBITORS OF FRUCTOSE 1,6-BISPHOSPHATASE AND METHODS OF USE THEREOF | TRUSTEES OF BOSTON COLLEGE (US) | 2012-02-02 | — | — | US | disclosed |
| US-20120028892-A1 | INHIBITORS OF FRUCTOSE 1,6-BISPHOSPHATASE AND METHODS OF USE THEREOF | TRUSTEES OF BOSTON COLLEGE (US) | 2012-02-02 | — | — | US | disclosed |
| WO-2010091185-A2 | INHIBITORS OF FRUCTOSE 1,6-BISPHOSPHATASE AND METHODS OF USE THEREOF | TRUSTEES OF BOSTON COLLEGE (US) | 2010-08-12 | — | — | WO | disclosed |
| WO-2010091185-A2 | INHIBITORS OF FRUCTOSE 1,6-BISPHOSPHATASE AND METHODS OF USE THEREOF | TRUSTEES OF BOSTON COLLEGE (US) | 2010-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028892-A1 | INHIBITORS OF FRUCTOSE 1,6-BISPHOSPHATASE AND METHODS OF USE THEREOF | FBP1, SLC5A1, ALDOA | FBP1 1/4885MAPT 2847/4885MEN1 1524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.