Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.41 |
| ▸ | CDK1 | P06493 | 2/20 | 0.41 |
| ▸ | CDK4 | P11802 | 2/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.41 |
| ▸ | CCND1 | P24385 | 2/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 5/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5045377 | 0.97 | MAPT (0.42) | ALDH1A1MAPTSMN1; SMN2LMNAGAA | |
| Hydrochloric Acid SCHEMBL4418636 | 0.95 | MAPT (0.42) | ALDH1A1MAPTSMN1; SMN2LMNAGAA | |
| SCHEMBL4433369 | 0.93 | LMNA (0.43) | ALDH1A1MAPTSMN1; SMN2LMNAGAA | |
| SCHEMBL5045534 | 0.88 | MAOB (0.42) | ALDH1A1MAPTSMN1; SMN2LMNAGAA | |
| SCHEMBL32672558 | 0.79 | HTR6 (0.58) | HTR6 | |
| SCHEMBL3923062 | 0.78 | ALDH1A1 (0.58) | ALDH1A1MAPTSMN1; SMN2LMNAGAA | |
| SCHEMBL2573793 | 0.78 | SLC6A9 (0.55) | ALDH1A1MAPTSMN1; SMN2LMNAGAA | |
| SCHEMBL32672532 | 0.78 | HTR6 (0.59) | HTR6 | |
| SCHEMBL5047347 | 0.77 | SLC6A9 (0.42) | ALDH1A1MAPTSMN1; SMN2LMNAGAA | |
| Hydrochloric Acid SCHEMBL4573223 | 0.77 | SLC6A9 (0.54) | ALDH1A1MAPTSMN1; SMN2LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656361-B1 | PIPERAZINE WITH OR-SUBSTITUTED PHENYL GROUP AND THEIR USE AS GLYT1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |