Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | ALPI | P09923 | 1/20 | 0.37 |
| ▸ | ALPG | P10696 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4714345 | 0.87 | LMNA (0.43) | CASRLMNAAKR1C3MEN1KMT2A | |
| SCHEMBL1857604 | 0.82 | CASR (0.40) | CASRLMNAAKR1C3MEN1KMT2A | |
| SCHEMBL4714343 | 0.80 | CASR (0.40) | CASRLMNAAKR1C3MEN1KMT2A | |
| SCHEMBL25737609 | 0.78 | CNR1 (0.37) | CASRLMNAAKR1C3MEN1KMT2A | |
| SCHEMBL4718006 | 0.76 | KMT2A (0.39) | LMNAMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL4714622 | 0.73 | TSHR (0.56) | LMNAMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL5047441 | 0.72 | BCHE (0.44) | LMNAMEN1KMT2AMAPTPOLB | |
| SCHEMBL5047436 | 0.69 | MAPT (0.36) | LMNAMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL4714646 | 0.69 | TSHR (0.47) | LMNAMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL4020745 | 0.68 | SMN1; SMN2 (0.48) | LMNAAKR1C3KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | disclosed |