Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TAS2R14 | Q9NYV8 | 8/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5049388 | 0.92 | TAS2R14 (0.47) | ALDH1A1POLBTAS2R14CYP2D6MAPT | |
| SCHEMBL5043143 | 0.90 | KMT2A (0.51) | ALDH1A1NPSR1TAS2R14TRPM8KMT2A | |
| SCHEMBL5047945 | 0.86 | TAS2R14 (0.58) | ALDH1A1NPSR1POLBTAS2R14KMT2A | |
| SCHEMBL5049449 | 0.86 | L3MBTL1 (0.43) | ALDH1A1POLBMAPTCHRM5CHRM1 | |
| SCHEMBL5133321 | 0.82 | FABP4 (0.49) | ALDH1A1POLBTAS2R14KMT2ACYP2D6 | |
| SCHEMBL5042984 | 0.82 | TAS2R14 (0.56) | ALDH1A1NPSR1TAS2R14MAPTLMNA | |
| SCHEMBL5043233 | 0.79 | RAB9A (0.49) | POLBMAPTCHRM5CHRM1 | |
| SCHEMBL5048100 | 0.78 | TAS2R14 (0.64) | ALDH1A1NPSR1TAS2R14TRPM8KMT2A | |
| SCHEMBL13399223 | 0.77 | TAS2R14 (0.60) | ALDH1A1NPSR1POLBTAS2R14TRPM8 | |
| SCHEMBL5043219 | 0.77 | TAS2R14 (0.45) | ALDH1A1TAS2R14KMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442702-B2 | Treatment of bone disorders; carboxy derivatives | PFIZER INC. (US) | 2008-10-28 | — | — | US | disclosed |
| EP-1021410-B1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER (US) | 2006-12-27 | — | — | EP | disclosed |
| US-6498172-B1 | (3-(((4-TERT-BUTYL-BENZYL)-(PYRIDINE-3-SULFONYL)-AMINO)-METHYL) -PHENOXY)-ACETIC ACID OR SALT; TREATING SUCH AS OSTEOPOROSIS | PFIZER INC. | 2002-12-24 | — | — | US | disclosed |
| EP-1021410-A1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER INC. (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1999019300-A1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER INC. (US) | 1999-04-22 | — | — | WO | disclosed |