Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | EPRS1 | P07814 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | LATS1 | O95835 | 3/20 | 0.41 |
| ▸ | LATS2 | Q9NRM7 | 3/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5045730 | 0.87 | ACHE (0.53) | ACHEMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL4824379 | 0.86 | ACHE (0.71) | ACHEEPRS1MAPTALDH1A1KDM4E | |
| SCHEMBL4824891 | 0.82 | ACHE (0.51) | ACHEEPRS1MAPTALDH1A1KDM4E | |
| SCHEMBL5349212 | 0.82 | ACHE (0.51) | ACHEEPRS1MAPTALDH1A1KDM4E | |
| SCHEMBL4830606 | 0.82 | ACHE (0.51) | ACHEEPRS1MAPTALDH1A1KDM4E | |
| SCHEMBL4824929 | 0.82 | EPRS1 (0.68) | ACHEEPRS1MAPTALDH1A1KDM4E | |
| SCHEMBL24505991 | 0.81 | ACHE (0.80) | ACHEMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL4824378 | 0.78 | KDM4E (0.54) | ACHEEPRS1MAPTALDH1A1KDM4E | |
| SCHEMBL29650635 | 0.78 | LATS1 (0.56) | ACHELATS1LATS2 | |
| SCHEMBL4823657 | 0.75 | ACHE (0.51) | ACHEEPRS1MAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7314939-B2 | Compositions and methods for inhibiting TGF-β | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-01-01 | — | — | US | disclosed |
| US-20050032835-A1 | Compositions and methods for inhibiting TGF-beta | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032835-A1 | Compositions and methods for inhibiting TGF-beta | TGFBR1, TGFB1, TGFBR2 | ACHE 1609/4885EPRS1 1837/4885MAPT 2637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.