Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | MMP1 | P03956 | 1/20 | 0.53 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | MMP9 | P14780 | 1/20 | 0.53 |
| ▸ | MMP12 | P39900 | 1/20 | 0.53 |
| ▸ | IDO1 | P14902 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.49 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.49 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1790733 | 0.84 | ALDH1A1 (0.58) | ALDH1A1MMP1MMP2MMP9MMP12 | |
| SCHEMBL28702044 | 0.84 | ALDH1A1 (0.58) | ALDH1A1MMP1MMP2MMP9MMP12 | |
| SCHEMBL1790735 | 0.82 | ALDH1A1 (0.56) | ALDH1A1MMP1MMP2MMP9MMP12 | |
| SCHEMBL30211075 | 0.81 | ALDH1A1 (0.64) | ALDH1A1MMP1MMP2MMP9MMP12 | |
| SCHEMBL7816660 | 0.81 | ALDH1A1 (0.55) | ALDH1A1MMP1MMP2MMP9MMP12 | |
| SCHEMBL5766366 | 0.81 | ALDH1A1 (0.64) | ALDH1A1MMP1MMP2MMP9MMP12 | |
| SCHEMBL3231685 | 0.81 | ALDH1A1 (0.59) | ALDH1A1MMP1MMP2MMP9MMP12 | |
| SCHEMBL28702045 | 0.79 | ALDH1A1 (0.53) | ALDH1A1MMP1MMP2MMP9MMP12 | |
| SCHEMBL19765221 | 0.79 | ALDH1A1 (0.54) | ALDH1A1MMP1MMP2MMP9MMP12 | |
| SCHEMBL2577721 | 0.79 | ALDH1A1 (0.50) | ALDH1A1MMP1MMP2MMP9MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080280965-A1 | Novel tetrahydrocarbazole derivatives having improved biological action and improved solubility as ligands of G-protein coupled receptors (GPCPs) | KLAUS PAULINI, ET AL. | 2008-11-13 | — | — | US | disclosed |
| US-7375127-B2 | Tetrahydrocarbazole derivatives having improved biological action and improved solubility as ligands of G-protein coupled receptors (GPCRs) | AE ZENTARIS GMBH (DE) | 2008-05-20 | — | — | US | disclosed |
| US-20060014818-A1 | Novel tetrahydrocarbazole derivatives having improved biological action and improved solubility as ligands of G-protein coupled receptors (GPCRs) | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT | 2006-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060014818-A1 | Novel tetrahydrocarbazole derivatives having improved biological action and improved solubility as ligands of G-protein coupled receptors (GPCRs) | GPR88, GPR34, GPR35 | ALDH1A1 3119/4885MMP1 3011/4885MMP2 2616/4885 |
| US-20080280965-A1 | Novel tetrahydrocarbazole derivatives having improved biological action and improved solubility as ligands of G-protein coupled receptors (GPCPs) | GPR35, GPR88, GPBAR1 | ALDH1A1 3429/4885MMP1 2931/4885MMP2 3054/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.