Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10972114 | 0.78 | ALOX15 (0.45) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL9574262 | 0.77 | ALDH1A1 (0.33) | ALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL2911815 | 0.75 | TP53 (0.46) | KDM4EALDH1A1MAPTTP53HPGD | |
| SCHEMBL7526557 | 0.75 | — | — | |
| SCHEMBL10372129 | 0.73 | ALDH1A1 (0.50) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL10374434 | 0.72 | CA12 (0.61) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL11201624 | 0.72 | ALDH1A1 (0.48) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL7186712 | 0.71 | TSHR (0.44) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL10835149 | 0.71 | CYP3A4 (0.59) | ALOX15HSD17B10TDP1 | |
| SCHEMBL2303871 | 0.70 | NR1H2 (0.50) | KDM4EMEN1ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192178-A2 | RUFOMYCINS AND DERIVATIVES THEREOF USEFUL AS INHIBITORS OF MULTI-DRUG RESISTANCE ASSOCIATED PROTEIN-1 (MRP-1) | ELI LILLY AND COMPANY (US) | 2002-04-03 | — | — | EP | claimed |
| WO-2000078795-A2 | RUFOMYCINS AND DERIVATIVES THEREOF USEFUL AS INHIBITORS OF MULTI-DRUG RESISTANCE ASSOCIATED PROTEIN-1 (MRP-1) | ELI LILLY AND COMPANY (US) | 2000-12-28 | — | — | WO | claimed |
| US-20080171211-A1 | Using electrically conductive polymer which during change in potential releases anions which inhibit the anodic or/and cathodic partial reaction of corrosion or/and releases adhesion-promoting anions | CHEMETALL GMBH (DE) | 2008-07-17 | — | — | US | disclosed |