Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | TTR | P02766 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | DHFR | P00374 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ALB | P02768 | 1/20 | 0.50 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.50 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.48 |
| ▸ | BAD | Q92934 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5571280 | 0.87 | HSD17B10 (0.59) | KDM4ETTRHSD17B10ACMSDMEN1 | |
| SCHEMBL30585141 | 0.87 | BCL2L1 (0.52) | KDM4ETTRHSD17B10ACMSDMEN1 | |
| SCHEMBL26639280 | 0.87 | BCL2L1 (0.52) | KDM4ETTRHSD17B10ACMSDMEN1 | |
| SCHEMBL5728666 | 0.86 | HNF4A (0.48) | KDM4EACMSDMEN1ALDH1A1LMNA | |
| SCHEMBL9419340 | 0.85 | SMN1; SMN2 (0.47) | KDM4ETTRHSD17B10ACMSDMEN1 | |
| SCHEMBL9358502 | 0.83 | SLC6A4 (0.51) | KDM4ETTRHSD17B10ACMSDMEN1 | |
| SCHEMBL9419262 | 0.81 | RAB9A (0.50) | ALDH1A1CYP2C19 | |
| SCHEMBL9419243 | 0.81 | SMN1; SMN2 (0.64) | KDM4EMEN1ALDH1A1CA1CA2 | |
| SCHEMBL9419351 | 0.79 | MCL1 (0.52) | — | |
| SCHEMBL18873501 | 0.79 | HSD17B10 (0.53) | KDM4EHSD17B10USP2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9006454-B2 | Dihydroorotate dehydrogenase inhibitors | MERCK SERONO S.A. (CH) | 2015-04-14 | — | — | US | disclosed |
| US-20120028959-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | MERCK SERONO S.A. (CH) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028959-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | DHODH, FH, DPYD | KDM4E 806/4885TTR 3466/4885HSD17B10 199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.