Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 16/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9820079 | 0.99 | HPSE (0.72) | HPSEKDM4EMAPTTP53SMN1; SMN2 | |
| Methane SCHEMBL5476423 | 0.87 | HPSE (0.70) | HPSEKDM4EMAPTTP53SMN1; SMN2 | |
| Methane SCHEMBL505763 | 0.87 | HPSE (0.70) | HPSEKDM4EMAPTSMN1; SMN2GAA | |
| SCHEMBL507169 | 0.87 | KDM4E (0.77) | HPSEKDM4ESMN1; SMN2GAA | |
| Methane SCHEMBL25304065 | 0.86 | HPSE (0.69) | HPSEKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL11626342 | 0.86 | HPSE (0.72) | HPSEKDM4EMAPTSMN1; SMN2GAA | |
| SCHEMBL5461475 | 0.86 | HPSE (0.72) | HPSEKDM4EMAPTTP53SMN1; SMN2 | |
| SCHEMBL14581706 | 0.85 | HPSE (0.70) | HPSEKDM4EGAA | |
| SCHEMBL20515142 | 0.82 | HPSE (1.00) | HPSEKDM4E | |
| SCHEMBL5641397 | 0.82 | MAPT (0.55) | HPSEKDM4EMAPTTP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120029226-A1 | METHOD FOR THE SYNTHESIS OF CHIRAL ALPHA-ARYL PROPIONIC ACID DERIVATIVES | DSM IP ASSETS B.V. (NL) | 2012-02-02 | — | — | US | claimed |
| EP-2393771-A1 | Method for the synthesis of chiral alpha-aryl propionic acid derivatives | DSM IP Assets B.V. (NL) | 2011-12-14 | — | — | EP | claimed |
| WO-2010089343-A1 | METHOD FOR THE SYNTHESIS OF CHIRAL ALPHA-ARYL PROPIONIC ACID DERIVATIVES | DSM IP ASSETS B.V. (NL) | 2010-08-12 | — | — | WO | claimed |
| CN-1747731-A | Imidazopyridines containing combinations and their use in treating gastrointestinal inflammatory disorders | ALTANA PHARMA AG (DE) | 2006-03-15 | — | — | CN | claimed |
| CN-1625411-A | Combination of a NSAID and a PDE-4 inhibitor | ALTANA PHARMA AG (DE) | 2005-06-08 | — | — | CN | claimed |
| US-20120029226-A1 | METHOD FOR THE SYNTHESIS OF CHIRAL ALPHA-ARYL PROPIONIC ACID DERIVATIVES | DSM IP ASSETS B.V. (NL) | 2012-02-02 | — | — | US | disclosed |
| EP-2393771-A1 | Method for the synthesis of chiral alpha-aryl propionic acid derivatives | DSM IP Assets B.V. (NL) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010089343-A1 | METHOD FOR THE SYNTHESIS OF CHIRAL ALPHA-ARYL PROPIONIC ACID DERIVATIVES | DSM IP ASSETS B.V. (NL) | 2010-08-12 | — | — | WO | disclosed |
| US-20070043003-A1 | Novel compounds for the prophylaxis and treatment of inflammatory bowel diseases | HIKMA PHARMACEUTICALS CO., LTD. (JO) | 2007-02-22 | — | — | US | disclosed |
| EP-1688413-A1 | Benzoxazole derivatives for the prophylaxis and treatment of inflammatory bowel diseases | Hikma Pharmaceuticals Co. Ltd. (JO) | 2006-08-09 | — | — | EP | disclosed |
| US-4416892-A | ANTIALLERGENS | LILLY INDUSTRIES LIMITED (GB) | 1983-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120029226-A1 | METHOD FOR THE SYNTHESIS OF CHIRAL ALPHA-ARYL PROPIONIC ACID DERIVATIVES | GRIA1, GRIA3, GRIA2 | HPSE 1312/4885KDM4E 3746/4885MAPT 2292/4885 |
| US-20070043003-A1 | Novel compounds for the prophylaxis and treatment of inflammatory bowel diseases | SI, ALPI, VIP | HPSE 811/4885KDM4E 1883/4885MAPT 4720/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.