Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | MAOB | P27338 | 5/20 | 0.58 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.55 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.52 |
| ▸ | PRKX | P51817 | 1/20 | 0.52 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.52 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.52 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.51 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.51 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 2/20 | 0.49 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1115026 | 0.89 | MEN1 (0.67) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9440728 | 0.88 | MEN1 (0.66) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2323743 | 0.88 | MEN1 (0.55) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30254080 | 0.88 | MAOB (0.61) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9547750 | 0.87 | MAOB (0.74) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4939266 | 0.86 | MAOB (0.60) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5383428 | 0.85 | KMT2A (0.63) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10658498 | 0.84 | MEN1 (0.62) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11751536 | 0.84 | MEN1 (0.62) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28065631 | 0.84 | ALDH1A1 (0.62) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110099893-A | A kind of preparation method for bending western DOPA and its intermediate | 广东东阳光药业有限公司 | 2019-08-06 | — | — | CN | claimed |
| CN-110099893-A | A kind of preparation method for bending western DOPA and its intermediate | 广东东阳光药业有限公司 | 2019-08-06 | — | — | CN | disclosed |
| CN-109370614-A | A kind of aligning agent for liquid crystal, liquid crystal orientation film and liquid crystal display element | 中节能万润股份有限公司 | 2019-02-22 | — | — | CN | disclosed |
| US-8338459-B2 | Compounds, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding | FOLDRX PHARMACEUTICALS, INC. (US) | 2012-12-25 | — | — | US | disclosed |
| CN-102316733-A | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | INST MEDICAL W & E HALL | 2012-01-11 | — | — | CN | disclosed |
| US-20110092545-A1 | Compounds, Compositions and Methods for Stabilizing Transthyretin and Inhibiting Transthyretin Misfolding | FoldRx Pharmaceuticals, Inc., a Massachusetts corporation | 2011-04-21 | — | — | US | disclosed |
| US-7868033-B2 | Compounds, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding | FOLDRX PHARMACEUTICALS, INC. (US) | 2011-01-11 | — | — | US | disclosed |
| US-20080161294-A1 | Urea derivative, medicinal composition containing the same, and medicinal use of these | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2008-07-03 | — | — | US | disclosed |
| EP-1867639-A1 | UREA DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND MEDICINAL USE OF THESE | Kissei Pharmaceutical Co., Ltd. (JP) | 2007-12-19 | — | — | EP | disclosed |
| US-5328641-A | Naphthalene ester derivatives with trifluoromethyl groups | SHOWA SHELL SEKIYU KABUSHIKI KAISHA | 1994-07-12 | — | — | US | disclosed |
| US-5207947-A | Trifluoroalkyl diaryl triesters; antiferroelectricity; electrooptics | SHOWA SHELL SEKIYU KABUSHIKI KAISHA (JP) | 1993-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161294-A1 | Urea derivative, medicinal composition containing the same, and medicinal use of these | AVPR2, UTS2R, GPR119 | MEN1 1124/4885KMT2A 3949/4885NPC1 2311/4885 |
| US-20110092545-A1 | Compounds, Compositions and Methods for Stabilizing Transthyretin and Inhibiting Transthyretin Misfolding | TTR, ALB, TTPA | MEN1 3274/4885KMT2A 3793/4885NPC1 1430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.