Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 9/20 | 0.80 |
| ▸ | GABRD | O14764 | 9/20 | 0.80 |
| ▸ | GABRA1 | P14867 | 9/20 | 0.80 |
| ▸ | GABRB1 | P18505 | 9/20 | 0.80 |
| ▸ | GABRG2 | P18507 | 9/20 | 0.80 |
| ▸ | GABRB3 | P28472 | 9/20 | 0.80 |
| ▸ | GABRA5 | P31644 | 9/20 | 0.80 |
| ▸ | GABRA3 | P34903 | 9/20 | 0.80 |
| ▸ | GABRA2 | P47869 | 9/20 | 0.80 |
| ▸ | GABRB2 | P47870 | 9/20 | 0.80 |
| ▸ | GABRA4 | P48169 | 9/20 | 0.80 |
| ▸ | GABRE | P78334 | 9/20 | 0.80 |
| ▸ | GABRA6 | Q16445 | 9/20 | 0.80 |
| ▸ | GABRG1 | Q8N1C3 | 9/20 | 0.80 |
| ▸ | GABRG3 | Q99928 | 9/20 | 0.80 |
| ▸ | GABRQ | Q9UN88 | 9/20 | 0.80 |
| ▸ | TNKS | O95271 | 3/20 | 0.75 |
| ▸ | PARP1 | P09874 | 3/20 | 0.75 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.75 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4607216 | 0.89 | GABRP (1.00) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7568626 | 0.86 | TNKS (1.00) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL30310999 | 0.84 | GABRP (1.00) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL16894631 | 0.84 | GABRP (0.81) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL4454279 | 0.84 | GABRP (1.00) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL6656060 | 0.82 | GABRP (0.82) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL11847987 | 0.81 | GABRP (0.61) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL4627823 | 0.79 | GABRP (0.82) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Flavone SCHEMBL18879 | 0.78 | TNKS (1.00) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Flavone SCHEMBL15676601 | 0.78 | TNKS (1.00) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165403-A1 | METHODS OF INHIBITING THE ACTIVITY OF HSP90 AND/OR ARYL HYDROCARBON RECEPTOR | UNIVERSITY OF ROCHESTER (US) | 2012-06-28 | — | — | US | disclosed |
| US-20080193932-A1 | Methods Of Inhibiting the Activity of Hsp90 and/or Aryl Hydrocarbon Receptor | UNIVERSITY OF ROCHESTER (US) | 2008-08-14 | — | — | US | disclosed |
| WO-2006052795-A2 | METHODS OF INHIBITING THE ACTIVITY OF HSP90 AND/OR ARYL HYDROCARBON RECEPTOR | UNIVERSITY OF ROCHESTER (US) | 2006-05-18 | — | — | WO | disclosed |